Fractal geometric analysis of material from molar and non-molar pregnancies

J Pathol. 1994 Jun;173(2):115-8. doi: 10.1002/path.1711730207.

Abstract

Histological sections from 25 non-molar pregnancies, nine partial hydatidiform moles, and 16 complete hydatidiform moles were examined (diagnosis was taken as the consensus of seven experienced histopathologists) and the fractal dimension was measured using a box-counting method implemented on a microcomputer-based image analysis system. The fractal dimensions of the different diagnostic categories were normally distributed with a mean of 1.50 for non-molar pregnancies, 1.44 for partial moles, and 1.42 for complete moles. All the measured fractal dimensions were greater than the topological dimension (1), demonstrating that the specimens had a fractal element to their structure. There was a significant difference between the fractal dimensions of non-molar pregnancies and complete moles (P = 0.0005), but not between partial moles and non-molar pregnancies (P = 0.0823) or complete and partial moles (P = 0.4400). Using the fractal dimension to predict the histopathological diagnosis assigned 56 per cent of the cases to the correct category with a kappa statistic of 0.26, so the fractal dimension, used alone, is not a useful morphometric discriminant in the diagnosis of molar and non-molar pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Fractals*
  • Humans
  • Hydatidiform Mole / diagnosis
  • Hydatidiform Mole / pathology*
  • Image Processing, Computer-Assisted
  • Microcomputers
  • Pregnancy
  • Trophoblasts / pathology*
  • Uterine Neoplasms / diagnosis
  • Uterine Neoplasms / pathology*