Abstract
5 alpha-Pregnan-3 alpha ol-20-one (3 alpha-OH-DHP) reduced the depolarization-induced loss of GABA and, to a lesser extent, the glutamate-like immunoreactivities from nerve terminals in the in vitro hippocampal slice. Phenobarbital (PB) had similar effects. These results suggest that 3 alpha-OH-DHP affects presynaptic transmitter release, possibly in a barbiturate-like manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Female
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Glutamates / metabolism*
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Glutamic Acid
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Hippocampus / metabolism*
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Immunohistochemistry
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Nerve Endings / metabolism*
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Potassium / pharmacology*
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Pregnanolone / pharmacology*
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Progesterone / metabolism
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Rats
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Rats, Sprague-Dawley
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gamma-Aminobutyric Acid / metabolism*
Substances
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Glutamates
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Glutamic Acid
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Progesterone
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gamma-Aminobutyric Acid
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Pregnanolone
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Potassium