The progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one reduces K(+)-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: a semiquantitative immunocytochemical study

Brain Res. 1993 Oct 1;623(2):329-33. doi: 10.1016/0006-8993(93)91448-2.

Abstract

5 alpha-Pregnan-3 alpha ol-20-one (3 alpha-OH-DHP) reduced the depolarization-induced loss of GABA and, to a lesser extent, the glutamate-like immunoreactivities from nerve terminals in the in vitro hippocampal slice. Phenobarbital (PB) had similar effects. These results suggest that 3 alpha-OH-DHP affects presynaptic transmitter release, possibly in a barbiturate-like manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Glutamates / metabolism*
  • Glutamic Acid
  • Hippocampus / metabolism*
  • Immunohistochemistry
  • Nerve Endings / metabolism*
  • Potassium / pharmacology*
  • Pregnanolone / pharmacology*
  • Progesterone / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Glutamates
  • Glutamic Acid
  • Progesterone
  • gamma-Aminobutyric Acid
  • Pregnanolone
  • Potassium