The pipelle is a device for collecting tissue from the uterine cavity, thereby also allowing morphological assessment of the endometrium, such as cyclus stages and hyperplasias. The biopsy is taken without use of anaesthetics and is a rapid and simple procedure. We have compared the Pipelle with the Endocyt device in 50 women and conclude that the pipelle method is just as simple to perform as the endocyt method and is tolerated just as well. The pipelle method represents an alternative to diagnostic curettage and deserves to be used more extensively.