Pharmacokinetics and relative bioavailability of nimodipine capsules and tablets in 8 Chinese healthy men

Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):295-7.

Abstract

A single oral dose of tablets or capsules of 239 mumol nimodipine was given to 8 healthy volunteers of Han nationality in a randomized crossover study. Plasma levels were determined with HPLC method. The plasma concentration-time curve fitted to a first order absorption, 1-compartment open model, and the T1/2K was around 2 h. Although the capsules could reach peak level faster, the bioavailability was not significantly different from that of the tablets.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Biological Availability
  • Capsules
  • Chromatography, High Pressure Liquid
  • Humans
  • Male
  • Nimodipine / administration & dosage
  • Nimodipine / pharmacokinetics*
  • Tablets

Substances

  • Capsules
  • Tablets
  • Nimodipine