Inflammatory airways disease is an uncommon but recognized complication of ulcerative colitis (UC). The present study was undertaken to determine the computed tomographic (CT) and high-resolution CT appearances of this entity. A retrospective review was performed of the radiographs and CT scans of seven patients (ages 24 to 54 years) with UC who presented with cough and recurrent respiratory infections. Four patients had total colectomies, and one had sigmoid colectomy. Fiberoptic bronchoscopy in six subjects showed diffuse mucosal erythema and edema that was most severe in the proximal airways. Sinus radiographs revealed maxillary sinus mucosal thickening in four patients and ethmoid sinus involvement in two. Chest radiographs showed bronchiectasis in two patients and bronchial wall thickening in three; radiographs were normal in two patients. CT features included bronchiectasis in six patients, peripheral airways involvement in four, and airway stenosis in three.