Abstract
We used [3H]glibenclamide binding to assess ATP-sensitive K+ channels in isolated cerebral microvessels and in the cerebral cortex of the rat. We found no measurable specific glibenclamide binding in cerebral microvessels despite its abundance in cerebral cortical membranes, implying that ATP-sensitive K+ channels are not present in cerebral microvessels.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphate / pharmacology*
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Animals
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Brain Chemistry / physiology*
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Capillaries / drug effects
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Capillaries / metabolism
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Cerebral Cortex / drug effects
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Cerebral Cortex / metabolism
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Glyburide / metabolism
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Glyburide / pharmacokinetics
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In Vitro Techniques
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Male
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Membranes / drug effects
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Membranes / metabolism
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Potassium Channels / drug effects
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Potassium Channels / metabolism*
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Rats
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Rats, Wistar
Substances
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Potassium Channels
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Adenosine Triphosphate
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Glyburide