Absence of linkage to the ataxia telangiectasia locus in familial breast cancer

R Wooster; D Ford; J Mangion; B A Ponder; J Peto; D F Easton; M R Stratton

doi:10.1007/BF00216153

Absence of linkage to the ataxia telangiectasia locus in familial breast cancer

Hum Genet. 1993 Aug;92(1):91-4. doi: 10.1007/BF00216153.

Authors

R Wooster¹, D Ford, J Mangion, B A Ponder, J Peto, D F Easton, M R Stratton

Affiliation

¹ Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.

PMID: 8365732
DOI: 10.1007/BF00216153

Abstract

Heterozygotes for ataxia-telangiectasia (AT) are known to have an increased risk of breast cancer. The gene (or genes) responsible for almost all cases of AT has been localised to chromosome 11q by genetic linkage analysis. To examine the possibility that AT heterozygosity may account for a substantial proportion of familial breast cancer, we have typed five markers on chromosome 11q in 16 breast cancer families. We have found no evidence for linkage between breast cancer and chromosome 11q markers and conclude that the contribution of AT to familial breast cancer is likely to be minimal.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ataxia Telangiectasia / genetics*
Breast Neoplasms / genetics*
Chromosomes, Human, Pair 11*
Female
Genetic Linkage
Heterozygote
Humans
Lod Score
Male