Sulfadoxine/pyrimethamine or chloroquine/clindamycin treatment of Gabonese school children infected with chloroquine resistant malaria

J Antimicrob Chemother. 1995 Oct;36(4):723-8. doi: 10.1093/jac/36.4.723.

Abstract

In a randomized trial, a high dosage chloroquine monotherapy (45 mg/kg over 3 days) was compared with combination regimens of sulfadoxine/pyrimethamine and chloroquine/clindamycin for treating Gabonese school children with Plasmodium falciparum malaria. In chloroquine treated patients only 32% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Antimalarials / administration & dosage
  • Antimalarials / adverse effects
  • Antimalarials / therapeutic use*
  • Child
  • Child, Preschool
  • Chloroquine / administration & dosage
  • Chloroquine / adverse effects
  • Chloroquine / therapeutic use
  • Clindamycin / administration & dosage
  • Clindamycin / adverse effects
  • Clindamycin / therapeutic use
  • Drug Combinations
  • Drug Resistance
  • Female
  • Gabon
  • Humans
  • Malaria, Falciparum / drug therapy*
  • Male
  • Parasitemia / drug therapy
  • Plasmodium falciparum / drug effects
  • Pyrimethamine / administration & dosage
  • Pyrimethamine / adverse effects
  • Pyrimethamine / therapeutic use
  • Sulfadoxine / administration & dosage
  • Sulfadoxine / adverse effects
  • Sulfadoxine / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Antimalarials
  • Drug Combinations
  • fanasil, pyrimethamine drug combination
  • Clindamycin
  • Sulfadoxine
  • Chloroquine
  • Pyrimethamine