Abstract
Fifty-one cases of esophageal squamous cell carcinoma were immunohistochemically investigated with monoclonal c-erbB 2 oncoprotein antibody. No tumor showed plasma membrane immunostaining for c-erbB-2 protein. Occasionally, unspecific cytoplasmic staining was found in minor tumor cell populations. The present results show that c-erbB-2 oncoprotein is not overexpressed in esophageal squamous cell carcinomas and does not play a central role in the tumorigenesis.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology
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Breast Neoplasms / chemistry
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Carcinoma, Squamous Cell / chemistry*
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Carcinoma, Squamous Cell / pathology
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Cytoplasm / chemistry
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Epithelium / chemistry
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Esophageal Neoplasms / chemistry*
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Esophageal Neoplasms / pathology
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Humans
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Immunoenzyme Techniques
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Mice
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Myeloma Proteins / analysis
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Neoplasm Proteins / analysis*
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Neoplasm Proteins / immunology
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Neoplasm Proteins / physiology
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Receptor, ErbB-2 / analysis*
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Receptor, ErbB-2 / immunology
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Receptor, ErbB-2 / physiology
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Retrospective Studies
Substances
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Antibodies, Monoclonal
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Myeloma Proteins
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Neoplasm Proteins
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Receptor, ErbB-2