Abstract
The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We carried out direct sequence analysis of human c-mos and human ENRB in a series of sporadic MTC and phaeochromocytomas to determine if somatic mutations in these two genes could account for some of the sporadic MEN 2-related tumours in which no RET mutations are detected. No somatic mutations were found.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adrenal Gland Neoplasms / genetics*
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Base Sequence
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Carcinoma, Medullary / genetics*
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Drosophila Proteins*
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Humans
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Molecular Sequence Data
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Multiple Endocrine Neoplasia Type 2a / genetics
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Mutation*
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Pheochromocytoma / genetics*
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-ret
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Proto-Oncogenes*
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Receptor Protein-Tyrosine Kinases / genetics*
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Receptor, Endothelin B
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Receptors, Endothelin / genetics*
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Thyroid Neoplasms / genetics*
Substances
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Drosophila Proteins
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MAS1 protein, human
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Receptor, Endothelin B
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Receptors, Endothelin
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases
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Ret protein, Drosophila