The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: an analysis of 618 individuals

Y L Ko; T S Hsu; S M Wu; Y S Ko; C J Chang; S M Wang; W J Chen; N J Cheng; C T Kuo; C W Chiang; Y S Lee

doi:10.1007/s004390050184

The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: an analysis of 618 individuals

Hum Genet. 1996 Aug;98(2):176-7. doi: 10.1007/s004390050184.

Authors

Y L Ko¹, T S Hsu, S M Wu, Y S Ko, C J Chang, S M Wang, W J Chen, N J Cheng, C T Kuo, C W Chiang, Y S Lee

Affiliation

¹ Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.

PMID: 8698336
DOI: 10.1007/s004390050184

Abstract

To understand the allele frequency of the G1691A mutation of the coagulation factor V gene (factor V Leiden) in Chinese, 618 Chinese individuals, including 54 cases with venous thrombosis, were analyzed. Only one case in the control group was heterozygous for the 1691G allele and the 1691A allele. Our data suggest that the factor V Leiden is rare in Chinese.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Case-Control Studies
China
Factor V / genetics*
Gene Frequency
Heterozygote
Humans
Point Mutation*
Protein C / metabolism
Thrombophlebitis / blood
Thrombophlebitis / genetics

Substances

Protein C
factor V Leiden
Factor V