Secondary prevention in schizophrenia is still not good enough, and the authors of the articles in this issue of Schizophrenia Bulletin present important new knowledge that may increase earlier detection and treatment. This final article discusses some of their main findings in relation to clinical consequences and new research. We need more knowledge about the clinical characteristics of the prodromal phase and about the factors that influence the help-seeking behavior of patients and families in the early phases of schizophrenia. The new models presented for early detection and treatment are promising and should be replicated in other countries and on other continents.