A large multisite cancer family is linked to BRCA2

P Tonin; P Ghadirian; C Phelan; G M Lenoir; H T Lynch; F Letendre; D Belanger; M Monté; S A Narod

doi:10.1136/jmg.32.12.982

A large multisite cancer family is linked to BRCA2

J Med Genet. 1995 Dec;32(12):982-4. doi: 10.1136/jmg.32.12.982.

Authors

P Tonin¹, P Ghadirian, C Phelan, G M Lenoir, H T Lynch, F Letendre, D Belanger, M Monté, S A Narod

Affiliation

¹ Department of Medicine, McGill University, Montreal, Quebec, Canada.

Abstract

We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod = 3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
BRCA2 Protein
Breast Neoplasms / genetics*
Breast Neoplasms, Male / genetics*
Chromosomes, Human, Pair 13 / genetics*
Female
Humans
Male
Middle Aged
Neoplasm Proteins / genetics*
Pedigree
Prostatic Neoplasms / genetics
Transcription Factors / genetics*

Substances

BRCA2 Protein
Neoplasm Proteins
Transcription Factors