Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of beta-amyloid(1-40) protein

Neurosci Lett. 1995 Dec 8;201(2):155-8. doi: 10.1016/0304-3940(95)12161-7.

Abstract

We have previously shown that the continuous intracerebroventricular infusion of beta-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of beta-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The beta-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of beta-amyloid(1-40) in the brain may affect CNTF production in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / administration & dosage
  • Amyloid beta-Peptides / pharmacology*
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Ciliary Neurotrophic Factor
  • Depression, Chemical
  • Immunoenzyme Techniques
  • Injections, Intraventricular
  • Male
  • Nerve Growth Factors / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Peptide Fragments / pharmacology
  • Rats
  • Rats, Wistar

Substances

  • Amyloid beta-Peptides
  • Ciliary Neurotrophic Factor
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Peptide Fragments