Abstract
Misoprostol prevented gastric hemorrhage in dogs, each of which received aspirin (35 mg/kg body weight, orally q 8 hrs for 10 days). All dogs receiving aspirin alone had gastroscopic and histopathological lesions. No lesions were noted in four of five dogs given aspirin plus misoprostol (15 micrograms/kg body weight, q 8 hrs for five days; then 7.5 micrograms/kg body weight, q 8 hrs for five days). Four of 10 dogs receiving 15 micrograms/kg body weight of misoprostol developed diarrhea. The misoprostol dose was reduced to 7.5 micrograms/kg body weight, and the diarrhea subsided.
Publication types
-
Clinical Trial
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alprostadil / analogs & derivatives*
-
Animals
-
Aspirin / administration & dosage
-
Aspirin / adverse effects*
-
Body Weight / drug effects
-
Body Weight / physiology
-
Diarrhea / chemically induced
-
Diarrhea / veterinary
-
Dog Diseases / chemically induced
-
Dog Diseases / physiopathology
-
Dog Diseases / prevention & control*
-
Dogs
-
Dose-Response Relationship, Drug
-
Drug Therapy, Combination
-
Feces / chemistry
-
Female
-
Gastrointestinal Hemorrhage / chemically induced
-
Gastrointestinal Hemorrhage / prevention & control
-
Gastrointestinal Hemorrhage / veterinary*
-
Hemoglobins / analysis
-
Male
-
Misoprostol / adverse effects
-
Misoprostol / therapeutic use
-
Prostaglandins, Synthetic / therapeutic use*
-
Stomach / drug effects
-
Stomach / pathology
-
Stomach / physiology
-
Stomach Diseases / chemically induced
-
Stomach Diseases / prevention & control
-
Stomach Diseases / veterinary*
Substances
-
Hemoglobins
-
Prostaglandins, Synthetic
-
Misoprostol
-
Alprostadil
-
Aspirin