Abstract
The effect of dexamethasone (Dex) on the ability to invade type I collagen gel was investigated in two cell lines of oral squamous cell carcinoma (SCC). At concentrations higher than 10(-8) M, Dex significantly suppressed the invasive growth of SCC cells into the gel. The same concentrations of Dex led to a decrease in urokinase type plasminogen activator (u-PA) synthesis and an increase in plasminogen activator inhibitor type 1 (PAI-1) synthesis by SCC cells. These findings suggest that Dex inhibits the invasiveness of SCC cells by decreasing their proteolytic activity.
MeSH terms
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / metabolism
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Carcinoma, Squamous Cell / pathology*
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Collagen
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Dexamethasone / pharmacology*
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Gels
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Gene Expression Regulation, Neoplastic / drug effects*
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Humans
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Neoplasm Invasiveness / genetics
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Neoplasm Invasiveness / prevention & control*
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Neoplasm Metastasis
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Plasminogen Activator Inhibitor 1 / biosynthesis*
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Plasminogen Activator Inhibitor 1 / genetics
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Tongue Neoplasms / genetics
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Tongue Neoplasms / metabolism
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Tongue Neoplasms / pathology*
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Tumor Cells, Cultured / drug effects
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Urokinase-Type Plasminogen Activator / biosynthesis*
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Urokinase-Type Plasminogen Activator / genetics
Substances
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Gels
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Neoplasm Proteins
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Plasminogen Activator Inhibitor 1
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Dexamethasone
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Collagen
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Urokinase-Type Plasminogen Activator