Effect of dexamethasone on invasion of human squamous cell carcinoma cells into collagen gel

Cancer Lett. 1996 Nov 12;108(1):81-6. doi: 10.1016/s0304-3835(96)04396-0.

Abstract

The effect of dexamethasone (Dex) on the ability to invade type I collagen gel was investigated in two cell lines of oral squamous cell carcinoma (SCC). At concentrations higher than 10(-8) M, Dex significantly suppressed the invasive growth of SCC cells into the gel. The same concentrations of Dex led to a decrease in urokinase type plasminogen activator (u-PA) synthesis and an increase in plasminogen activator inhibitor type 1 (PAI-1) synthesis by SCC cells. These findings suggest that Dex inhibits the invasiveness of SCC cells by decreasing their proteolytic activity.

Publication types

  • Comparative Study

MeSH terms

  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / pathology*
  • Collagen
  • Dexamethasone / pharmacology*
  • Gels
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Humans
  • Neoplasm Invasiveness / genetics
  • Neoplasm Invasiveness / prevention & control*
  • Neoplasm Metastasis
  • Neoplasm Proteins / biosynthesis*
  • Neoplasm Proteins / genetics
  • Plasminogen Activator Inhibitor 1 / biosynthesis*
  • Plasminogen Activator Inhibitor 1 / genetics
  • Tongue Neoplasms / genetics
  • Tongue Neoplasms / metabolism
  • Tongue Neoplasms / pathology*
  • Tumor Cells, Cultured / drug effects
  • Urokinase-Type Plasminogen Activator / biosynthesis*
  • Urokinase-Type Plasminogen Activator / genetics

Substances

  • Gels
  • Neoplasm Proteins
  • Plasminogen Activator Inhibitor 1
  • Dexamethasone
  • Collagen
  • Urokinase-Type Plasminogen Activator