The neurochemistry of Alzheimer's disease

Acta Neurol Scand Suppl. 1996:168:77-86. doi: 10.1111/j.1600-0404.1996.tb00378.x.

Abstract

The last 15-20 years have seen a wealth of studies to characterize the neurochemical abnormalities of Alzheimer's disease, in particular those involving the beta-amyloid and tau proteins, as well as more recently, apolipoprotein E4. This article provides a summary of the evidence for the involvement of these proteins in Alzheimer's disease pathogenesis based on postmortem brain and CSF studies.

Publication types

  • Review

MeSH terms

  • Aged
  • Alzheimer Disease / pathology*
  • Amyloid beta-Protein Precursor / analysis*
  • Apolipoprotein E4
  • Apolipoproteins E / analysis*
  • Brain / pathology*
  • Humans
  • Membrane Proteins / analysis*
  • Neurofibrillary Tangles / pathology*
  • Presenilin-1
  • tau Proteins / analysis*

Substances

  • Amyloid beta-Protein Precursor
  • Apolipoprotein E4
  • Apolipoproteins E
  • Membrane Proteins
  • PSEN1 protein, human
  • Presenilin-1
  • tau Proteins