Comparison of the in vitro activities of Bay 12-8039, a new quinolone, and other antimicrobials against clinically important anaerobes

K E Aldridge; D S Ashcraft

doi:10.1128/AAC.41.3.709

Comparison of the in vitro activities of Bay 12-8039, a new quinolone, and other antimicrobials against clinically important anaerobes

Antimicrob Agents Chemother. 1997 Mar;41(3):709-11. doi: 10.1128/AAC.41.3.709.

Authors

K E Aldridge¹, D S Ashcraft

Affiliation

¹ Department of Medicine, Louisiana State University Medical Center, New Orleans 70112, USA.

Abstract

Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhibited 91 and 96% of the 410 test isolates at 2 and 4 micrograms/ml, respectively. Bay 12-8039 had activity comparable to that metronidazole and overall was at least 16-fold more active than ciprofloxacin, ofloxacin, and cefoxitin, 32-fold more active than cefotetan, and at least 128-fold more active than penicillin G.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
Aza Compounds*
Bacteria, Anaerobic / drug effects*
Bacterial Infections / microbiology
Fluoroquinolones*
Humans
Microbial Sensitivity Tests
Moxifloxacin
Quinolines*
Quinolones / pharmacology*

Substances

Anti-Infective Agents
Aza Compounds
Fluoroquinolones
Quinolines
Quinolones
Moxifloxacin