Abstract
A 34-year-old woman on interferon for CML for 7 years, experienced problems with conception. Full work-up revealed a short luteal phase and therapy with clomiphene was initiated. Pregnancy occurred and a normal infant was delivered by C-section. The detailed infertility evaluation is described and the impact of interferon therapy on pregnancy is reviewed. Successful pregnancy appears possible in woman taking interferon on a chronic basis.
MeSH terms
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Adult
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Agents, Alkylating / therapeutic use
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Clomiphene / therapeutic use
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Female
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Fertility Agents, Female / therapeutic use
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Humans
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Hydroxyurea / therapeutic use
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Infant, Newborn
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Infertility, Female / drug therapy
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Infertility, Female / etiology
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Interferon-alpha / pharmacokinetics
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Interferon-alpha / therapeutic use*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
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Male
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Maternal-Fetal Exchange
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Pregnancy
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Remission Induction
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Alkylating
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Fertility Agents, Female
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Interferon-alpha
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Clomiphene
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Hydroxyurea