Alpha-interferon and pregnancy in a patient with CML

Hematol Oncol. 1996 Sep;14(3):119-22. doi: 10.1002/(SICI)1099-1069(199609)14:3<119::AID-HON576>3.0.CO;2-Q.

Abstract

A 34-year-old woman on interferon for CML for 7 years, experienced problems with conception. Full work-up revealed a short luteal phase and therapy with clomiphene was initiated. Pregnancy occurred and a normal infant was delivered by C-section. The detailed infertility evaluation is described and the impact of interferon therapy on pregnancy is reviewed. Successful pregnancy appears possible in woman taking interferon on a chronic basis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Clomiphene / therapeutic use
  • Female
  • Fertility Agents, Female / therapeutic use
  • Humans
  • Hydroxyurea / therapeutic use
  • Infant, Newborn
  • Infertility, Female / drug therapy
  • Infertility, Female / etiology
  • Interferon-alpha / pharmacokinetics
  • Interferon-alpha / therapeutic use*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Male
  • Maternal-Fetal Exchange
  • Pregnancy
  • Remission Induction

Substances

  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Fertility Agents, Female
  • Interferon-alpha
  • Clomiphene
  • Hydroxyurea