Clinical features in patients with permanent visual loss due to biopsy-proven giant cell arteritis

Br J Rheumatol. 1997 Feb;36(2):251-4. doi: 10.1093/rheumatology/36.2.251.

Abstract

The objective was to determine associated clinical findings in patients with visual loss due to giant cell arteritis (GCA) by means of a record review of 146 patients with biopsy-proven GCA. Twenty-three (15.75%) patients had lost vision. All of these patients complained of classical GCA cranial symptoms for an average of 1.3 months, 34.8% had an apparent isolated polymyalgia rheumatica for an average of 10.8 months and 65.2% had premonitory visual symptoms before visual loss for an average of 8.5 days. A clear delay in diagnosis and treatment was present in 15 patients (65.2%) who complained of at least two classical cranial symptoms for longer than 3 weeks and/or who had presented premonitory visual symptoms for longer than 72 h before blindness. Two additional patients lost vision while receiving standard steroid therapy. In conclusion, a high proportion of patients with permanent visual loss have a delayed diagnosis and treatment. A wider recognition of the disease would potentially reduce the prevalence of irreversible visual loss among GCA patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Blindness / drug therapy
  • Blindness / etiology*
  • Blindness / pathology
  • Female
  • Giant Cell Arteritis / complications*
  • Giant Cell Arteritis / diagnosis
  • Glucocorticoids / therapeutic use
  • Humans
  • Male
  • Methylprednisolone / therapeutic use
  • Polymyalgia Rheumatica / pathology
  • Prednisone / therapeutic use
  • Retrospective Studies
  • Temporal Arteries / pathology*
  • Vision, Ocular / physiology

Substances

  • Glucocorticoids
  • Prednisone
  • Methylprednisolone