This study concerns 169 women whose exposure to simvastatin (Zocor or Lodales) during pregnancy led to a request for information from pharmaceutical firms. The evolution of pregnancies (among which 2 were twins) was documented in 125 women: 66 women gave birth to normal babies, 40 requested and induced abortion, 12 spontaneous abortions occurred, and the 9 other known pregnancy issues were 4 premature newborns, 3 newborns with malformations and 2 fetal deaths. Apart from the 5 retrospective files concerning 5 spontaneous abortions, all the files were analysed prospectively. Except for induced abortions, regarding the prospective files, the pregnancy outcome was comparable with that of a general population.