Abstract
Recent evidence suggests a role of angiotensin-converting enzyme (ACE) in diabetic nephropathy. The effect of diabetes and low protein diet on renal immunohistochemical ACE localization was studied in streptozotocin-induced DM rats. Immunohistochemical ACE localization was reduced in DM rats, and a low protein diet partially resolved this abnormality while inhibiting the progression of diabetic nephropathy.
MeSH terms
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Albuminuria
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Animals
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Blood Glucose / metabolism
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Blood Pressure
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Diabetes Mellitus, Experimental / enzymology*
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Diabetes Mellitus, Experimental / pathology
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Diabetes Mellitus, Experimental / physiopathology
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Diabetic Nephropathies / enzymology*
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Diabetic Nephropathies / pathology
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Diabetic Nephropathies / prevention & control*
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Diet, Protein-Restricted*
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Immunohistochemistry
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Kidney / enzymology*
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Kidney / pathology
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Male
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Peptidyl-Dipeptidase A / analysis*
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Rats
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Rats, Wistar
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Serum Albumin / metabolism
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Time Factors
Substances
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Blood Glucose
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Serum Albumin
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Peptidyl-Dipeptidase A