Renal angiotensin-converting enzyme localization in diabetic rats and the effect of low protein diet

Nephron. 1997;76(2):186-91. doi: 10.1159/000190167.

Abstract

Recent evidence suggests a role of angiotensin-converting enzyme (ACE) in diabetic nephropathy. The effect of diabetes and low protein diet on renal immunohistochemical ACE localization was studied in streptozotocin-induced DM rats. Immunohistochemical ACE localization was reduced in DM rats, and a low protein diet partially resolved this abnormality while inhibiting the progression of diabetic nephropathy.

MeSH terms

  • Albuminuria
  • Animals
  • Blood Glucose / metabolism
  • Blood Pressure
  • Diabetes Mellitus, Experimental / enzymology*
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / physiopathology
  • Diabetic Nephropathies / enzymology*
  • Diabetic Nephropathies / pathology
  • Diabetic Nephropathies / prevention & control*
  • Diet, Protein-Restricted*
  • Immunohistochemistry
  • Kidney / enzymology*
  • Kidney / pathology
  • Male
  • Peptidyl-Dipeptidase A / analysis*
  • Rats
  • Rats, Wistar
  • Serum Albumin / metabolism
  • Time Factors

Substances

  • Blood Glucose
  • Serum Albumin
  • Peptidyl-Dipeptidase A