Transient down-regulation of inhibin-betaC expression following partial hepatectomy

Biochem Biophys Res Commun. 1997 Jun 27;235(3):553-6. doi: 10.1006/bbrc.1997.6850.

Abstract

Inhibin-betaC is a recently described TGF-beta family member most homologous to inhibin-betaA and inhibin-betaB. By Northern analysis, inhibin-betaC mRNA was detected exclusively in the liver among a large number of adult mouse tissues surveyed. The expression of inhibin-betaC mRNA in adult liver dropped sharply and transiently following partial hepatectomy. At 6 and 12 hours following partial hepatectomy, the levels of inhibin-betaC mRNA were at least 8-fold lower than in control animals. The liver specificity of inhibin-betaC expression and its down-regulation following partial hepatectomy suggest that inhibin-betaC may function as a negative regulator of liver growth.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Gene Expression Regulation, Enzymologic*
  • Hepatectomy*
  • Inhibins / biosynthesis
  • Kinetics
  • Liver / metabolism*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Organ Specificity
  • Peptide Biosynthesis*
  • Prostatic Secretory Proteins*

Substances

  • Prostatic Secretory Proteins
  • beta-microseminoprotein
  • Inhibins