Abstract
The effect of 4-hydroxynonenal (4-HNE), a circulating lipid peroxidation product, on the vascular tone of human mesenteric arteries is studied. 4-HNE promotes relaxation of human mesenteric arterial rings in a concentration-dependent manner. Removal of the endothelium or treatment with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10(-4) M) partially prevented 4-HNE-induced relaxation, thus suggesting the intervention of nitric oxide from endothelial origin in the vascular effects of 4-HNE.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aldehydes / pharmacology*
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Endothelium, Vascular / physiology*
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Female
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Hemodynamics / drug effects
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Humans
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In Vitro Techniques
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Lipid Peroxidation / physiology
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Male
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Mesenteric Arteries / drug effects*
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Mesenteric Arteries / physiology
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Middle Aged
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects*
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Muscle, Smooth, Vascular / physiology
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NG-Nitroarginine Methyl Ester / pharmacology
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Nitric Oxide / pharmacology
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Norepinephrine / pharmacology
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Vasodilation / drug effects*
Substances
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Aldehydes
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Nitric Oxide
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4-hydroxy-2-nonenal
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NG-Nitroarginine Methyl Ester
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Norepinephrine