4-hydroxynonenal-induced relaxation of human mesenteric arteries

Free Radic Biol Med. 1997;23(3):521-3. doi: 10.1016/s0891-5849(97)00119-6.

Abstract

The effect of 4-hydroxynonenal (4-HNE), a circulating lipid peroxidation product, on the vascular tone of human mesenteric arteries is studied. 4-HNE promotes relaxation of human mesenteric arterial rings in a concentration-dependent manner. Removal of the endothelium or treatment with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10(-4) M) partially prevented 4-HNE-induced relaxation, thus suggesting the intervention of nitric oxide from endothelial origin in the vascular effects of 4-HNE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aldehydes / pharmacology*
  • Endothelium, Vascular / physiology*
  • Female
  • Hemodynamics / drug effects
  • Humans
  • In Vitro Techniques
  • Lipid Peroxidation / physiology
  • Male
  • Mesenteric Arteries / drug effects*
  • Mesenteric Arteries / physiology
  • Middle Aged
  • Muscle Contraction / drug effects
  • Muscle, Smooth, Vascular / drug effects*
  • Muscle, Smooth, Vascular / physiology
  • NG-Nitroarginine Methyl Ester / pharmacology
  • Nitric Oxide / pharmacology
  • Norepinephrine / pharmacology
  • Vasodilation / drug effects*

Substances

  • Aldehydes
  • Nitric Oxide
  • 4-hydroxy-2-nonenal
  • NG-Nitroarginine Methyl Ester
  • Norepinephrine