Evaluation of commercially available assays of neopterin and beta 2-microglobulin for the assessment of disease progression in FIV-infected cats

Vet Immunol Immunopathol. 1997 May;56(1-2):185-9. doi: 10.1016/s0165-2427(96)05724-8.

Abstract

Serum or plasma samples from cats at different stages of feline immunodeficiency (FIV) infection and from uninfected cats were tested using immunoassays designed to detect human neopterin and beta 2-microglobulin (beta 2M). The results obtained from the anti-human neopterin assay did not correlate with infection status, time post-infection, fCD4 count or clinical picture. Feline samples gave negative results in the anti-human beta 2M assay. The assay kits used in this study are not suitable for the determination of the effect of FIV infection on immune activation markers in the cat.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biopterins / analogs & derivatives*
  • Biopterins / analysis
  • Biopterins / immunology
  • Cat Diseases / diagnosis*
  • Cat Diseases / immunology
  • Cats
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay / veterinary
  • Feline Acquired Immunodeficiency Syndrome / diagnosis*
  • Feline Acquired Immunodeficiency Syndrome / immunology
  • Humans
  • Immunodeficiency Virus, Feline / immunology*
  • Neopterin
  • Reagent Kits, Diagnostic / veterinary*
  • beta 2-Microglobulin / analysis*
  • beta 2-Microglobulin / immunology

Substances

  • Reagent Kits, Diagnostic
  • beta 2-Microglobulin
  • Biopterins
  • Neopterin