Abstract
To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (x 2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Carrier Proteins / genetics*
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Case-Control Studies
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Disease Susceptibility
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Ethnicity / genetics
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Genotype
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Germany / ethnology
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Humans
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Italy / ethnology
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins*
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Nerve Tissue Proteins*
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Panic Disorder / epidemiology
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Panic Disorder / genetics*
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Polymorphism, Genetic*
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Promoter Regions, Genetic / genetics*
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Serotonin Plasma Membrane Transport Proteins
Substances
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins