Previous studies have shown that, when the pharyngeal muscles are relaxed, the velopharynx is a highly compliant segment of the pharynx. Thus, under these circumstances, cross-sectional area of the velopharynx (AVP), driving pressure across the velopharynx (DeltaP), and inspiratory airflow (VI) will be mutually interdependent variables. The purpose of the present investigation was to describe the interrelation among these three variables during inspiration. We studied 15 sleeping patients with obstructive sleep apnea/hypopnea when the pharyngeal muscles were rendered hypotonic by applying continuous positive airway pressure to the nasal airway. AVP, determined by endoscopic imaging, was significantly greater at onset of VI limitation than at minimum oropharyngeal pressure (P < 0. 01). Snoring was never observed during VI limitation. In a subgroup of six patients, values for DeltaP, VI, and AVP were obtained at 0. 1-s intervals at various levels of mask pressure. For these six patients, the mathematical expression VI = 0.657(AVP/Amax) . DeltaP0. 332, where Amax is maximal AVP, described the relationship among the three variables (R2 = 0.962) for flow-limited and non-flow-limited inspirations. The impedance of the passive velopharynx, defined as DeltaP0.33/V, was inversely related to AVP and increased dramatically when AVP was <0.3 cm2. In summary, we observed a progressive decrease in AVP during flow-limited inspiration in patients with obstructive sleep apnea. This constriction of the velopharynx contributes to an increase in velopharyngeal impedance that, in turn, counterbalances the increase in DeltaP during flow limitation.