Sesquiterpenoids of the drimane class from a sponge of the genus Dysidea

J Nat Prod. 1997 Nov;60(11):1115-20. doi: 10.1021/np9703297.

Abstract

Ten sesquiterpenoids, including seven new ones, have been isolated from an undescribed sponge of the genus Dysidea. Compounds 1-8 are sesquiterpenoids of the drimane class, while 9 and 10 are 12-norsesquiterpenoids of the same structural class. The structures of novel compounds have been determined by combined spectroscopic methods. These compounds exhibited moderate antimicrobial and enzyme inhibitory (Na+/K(+)-ATPase and PLA2) activities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / pharmacology
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Phospholipases A / antagonists & inhibitors
  • Phospholipases A2
  • Porifera / chemistry*
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Infective Agents
  • Enzyme Inhibitors
  • Sesquiterpenes
  • Phospholipases A
  • Phospholipases A2
  • Sodium-Potassium-Exchanging ATPase