Abstract
Seventy-six patients with stage I or IE intermediate-grade or immunoblastic non-Hodgkin's lymphoma were treated with a short course of doxorubicin-containing chemotherapy with (n = 58) or without (n = 18) involved field radiotherapy. Chemotherapy consisted of 3 or 4 cycles of M-BACOD or (bleo-)CHOP. Seventy-two (97%) of the 74 evaluable patients achieved a complete response. The 3-year overall survival was 89%, recurrence-free survival 94%, and lymphoma-specific survival 93%. Patients older than 60 years also had a 3-year lymphoma-specific survival rate of as high as 92%. The International Prognostic Index was associated with overall survival (p = 0.04), but not with lymphoma-specific survival (p = 0.18). We conclude that stages I and IE intermediate-grade or immunoblastic non-Hodgkin's Hodgkin's lymphoma is highly curable if treated with short doxorubicin-containing chemotherapy and involved field radiotherapy.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Dexamethasone / administration & dosage
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Doxorubicin / administration & dosage
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Female
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Humans
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Leucovorin / administration & dosage
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Lymphoma, Large-Cell, Immunoblastic / drug therapy*
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Lymphoma, Large-Cell, Immunoblastic / radiotherapy*
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Lymphoma, Non-Hodgkin / drug therapy*
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Lymphoma, Non-Hodgkin / radiotherapy*
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Male
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Methotrexate / administration & dosage
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Middle Aged
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Neoplasm Staging
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Prednisone / administration & dosage
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Retrospective Studies
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Vincristine / administration & dosage
Substances
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Bleomycin
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Vincristine
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Dexamethasone
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Doxorubicin
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Cyclophosphamide
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Leucovorin
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Prednisone
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Methotrexate
Supplementary concepts
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CHOP protocol
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CHOP-B protocol
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M-BACOD protocol