Comparison of sib-pair and variance-components methods for genomic screening

Genet Epidemiol. 1997;14(6):867-72. doi: 10.1002/(SICI)1098-2272(1997)14:6<867::AID-GEPI51>3.0.CO;2-K.

Abstract

The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Automation
  • Chromosome Mapping
  • Female
  • Genetic Markers*
  • Genetic Testing / methods*
  • Genome, Human*
  • Humans
  • Male
  • Matched-Pair Analysis
  • Nuclear Family*
  • Phenotype
  • Predictive Value of Tests

Substances

  • Genetic Markers