Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway

Structure. 1997 Dec 15;5(12):1543-50. doi: 10.1016/s0969-2126(97)00303-1.

Abstract

DNA base excision repair (BER) is essential to preserving the integrity of the genome. Recent crystallographic studies of representatives from each enzyme class required for BER reveal clues to the structural basis of an entire DNA repair pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Composition
  • Crystallography, X-Ray
  • DNA Repair*
  • Enzymes / chemistry*
  • Enzymes / genetics*
  • Enzymes / metabolism
  • Humans
  • Models, Molecular
  • Multigene Family
  • Structure-Activity Relationship

Substances

  • Enzymes