A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation

G Ott; B C Bastian; T Katzenberger; J F Decoteau; J Kalla; A Rosenwald; F Weissinger; M M Ott; M E Kadin; H K Müller-Hermelink

doi:10.1046/j.1365-2141.1998.00531.x

A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation

Br J Haematol. 1998 Jan;100(1):187-90. doi: 10.1046/j.1365-2141.1998.00531.x.

Authors

G Ott¹, B C Bastian, T Katzenberger, J F Decoteau, J Kalla, A Rosenwald, F Weissinger, M M Ott, M E Kadin, H K Müller-Hermelink

Affiliation

¹ Pathologisches Institut, University of Würzburg, Germany.

PMID: 9450809
DOI: 10.1046/j.1365-2141.1998.00531.x

Abstract

Cytogenetic investigations were performed in a case of a nodal malignant non-Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30-positive anaplastic large cell lymphoma (ALCL). A t(2;5)(p23;q35) chromosome translocation could be observed in all metaphases analysed. This finding was confirmed both by RT-PCR analysis of the NPM/ALK fusion protein and by positive staining with the p80(NPM/ALK) antibody. To the best of our knowledge, this is the first report of a t(2;5) documented by classic cytogenetics in the lymphohistiocytic variant of ALCL.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Chromosomes, Human, Pair 2 / genetics*
Chromosomes, Human, Pair 5 / genetics*
Female
Humans
Immunohistochemistry
Karyotyping
Lymphoma, Large-Cell, Anaplastic / genetics*
Translocation, Genetic*

Grants and funding

R01-CA54026/CA/NCI NIH HHS/United States