Abstract
Antibodies to an axolemma-enriched fraction (AEF) antigen have been detected in the cerebrospinal fluid (CSF) and serum of patients with Multiple Sclerosis (MS) using an enzyme-linked immunosorbent assay (ELISA). A marginal elevation (P < 0.08) of anti-AEF IgG was found in MS CSF when compared with OND samples. When CSF was diluted to a standardized IgG concentration, the anti-AEF IgG level in MS CSF was significantly elevated (P=0.007) when compared to OND CSF. MS serum was also found to contain a significantly higher level (P < 0.001) of anti-AEF IgG when compared to OND serum using the ELISA technique.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Autoantibodies / analysis*
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Autoantibodies / cerebrospinal fluid*
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Axons / immunology*
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Cell Membrane / immunology
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Immunoglobulin G / cerebrospinal fluid
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Male
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Middle Aged
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Multiple Sclerosis / blood
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Multiple Sclerosis / cerebrospinal fluid*
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Multiple Sclerosis / immunology*
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Nervous System Diseases / blood
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Nervous System Diseases / cerebrospinal fluid*
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Nervous System Diseases / immunology*
Substances
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Autoantibodies
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Immunoglobulin G