Fluorinated anesthetics differ in toxic effects on peritoneum and subjacent tissues

J Appl Toxicol. 1998 Jan-Feb;18(1):79-80. doi: 10.1002/(sici)1099-1263(199801/02)18:1<79::aid-jat477>3.0.co;2-a.

Abstract

Intraperitoneal injection of fluorinated anesthetics produced anesthesia in rats. This was followed by toxic effects on peritoneal organs and surfaces, except for sevoflurane, which did not produce any lesions.

Publication types

  • Comparative Study

MeSH terms

  • Anesthesia / mortality
  • Anesthetics, Inhalation / administration & dosage
  • Anesthetics, Inhalation / toxicity*
  • Animals
  • Female
  • Halothane / administration & dosage
  • Halothane / toxicity*
  • Injections, Intraperitoneal
  • Isoflurane / administration & dosage
  • Isoflurane / toxicity*
  • Methoxyflurane / administration & dosage
  • Methoxyflurane / toxicity*
  • Methyl Ethers / administration & dosage
  • Methyl Ethers / toxicity*
  • Peritoneum / drug effects*
  • Peritoneum / pathology
  • Rats
  • Rats, Inbred Lew
  • Sevoflurane
  • Structure-Activity Relationship

Substances

  • Anesthetics, Inhalation
  • Methyl Ethers
  • Methoxyflurane
  • Sevoflurane
  • Isoflurane
  • Halothane