Effect of metoprolol in reducing myocardial ischemic threshold during exercise and during daily activity

Am J Cardiol. 1998 Mar 15;81(6):775-7. doi: 10.1016/s0002-9149(97)01015-1.

Abstract

In a study of 48 patients with coronary artery disease and evidence of ischemia during exercise and daily life, metoprolol reduced the threshold of myocardial ischemia in a dose-dependent manner. This effect of beta blockers is probably due to increased coronary tone.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living*
  • Adrenergic beta-Antagonists / pharmacology*
  • Blood Pressure
  • Dose-Response Relationship, Drug
  • Electrocardiography, Ambulatory
  • Exercise*
  • Heart Rate
  • Humans
  • Metoprolol / pharmacology*
  • Myocardial Ischemia / physiopathology
  • Myocardial Ischemia / prevention & control*

Substances

  • Adrenergic beta-Antagonists
  • Metoprolol