The role of intergenerational discrepancy for cultural orientation was examined in the etiology of drug use among Latina adolescents and in the context of family support. Intergenerational discrepancy occurs when a family member of one generation differs from a family member of another generation in cultural identity factors; this is usually manifested in conflict between a first generation child and the immigrant generation parent. It was hypothesized that the Latina adolescents experiencing intergenerational discrepancy might use drugs more frequently than Latina adolescents who were not; and that family support would be an important moderator of the relationship. A sample of 295 ninth and tenth grade Latina students (approximately 80% Mexican-American) from four Los Angeles area schools were surveyed as part of a larger study. In this secondary analysis, a 2 (family support ) x 2 (discrepancy) ANOVA revealed that intergenerational discrepancy was associated with more drug use in certain cases, and that family support did not moderate this relationship. Results partially validate and extend a theoretical model presented by Szapocznik and Kurtines (1980), and indicate a need to focus on cultural variables when intervening in drug use/misuse among Latina adolescents.