Abstract
N-chloroethyl derivatives of 7-hydroxy-1,2,3,4-tetrahydronaphthalene (7-OH-DPAT), 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), or fluphenazine were microinjected into rat nucleus accumbens (Acc), and receptor binding quantified autoradiographically after 24 h. EEDQ reduced [3H]nemonapride (D2-like receptors) binding in Acc (by 84%) and islands of Calleja (IC; 44%), without affecting [3H](+)-7-OH-DPAT (D3); N-chloroethyl-7-OH-DPATs blocked both radioligands in Acc and IC (30%-70%); fluphenazine had no effect.
Copyright 1998 Elsevier Science B.V.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkylating Agents / pharmacology*
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Animals
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Autoradiography
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Bacterial Toxins / pharmacology
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Calcium-Binding Proteins*
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Dopamine Agonists / pharmacology
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Dopamine Antagonists / pharmacology*
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Fluphenazine / pharmacology
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Male
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Microinjections
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Nucleus Accumbens / chemistry
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Nucleus Accumbens / drug effects
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Prosencephalon / chemistry*
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Prosencephalon / drug effects
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Quinolines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine D2 / physiology*
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Receptors, Dopamine D3
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Tetrahydronaphthalenes / pharmacology
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Type C Phospholipases / pharmacology
Substances
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Alkylating Agents
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Bacterial Toxins
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Calcium-Binding Proteins
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Dopamine Agonists
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Dopamine Antagonists
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Drd3 protein, rat
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Quinolines
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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Tetrahydronaphthalenes
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EEDQ
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Type C Phospholipases
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alpha toxin, Clostridium perfringens
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7-hydroxy-2-N,N-dipropylaminotetralin
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Fluphenazine