Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: autoradiographic assessment of D2-like and D3 sites

Brain Res. 1998 May 11;792(2):324-6. doi: 10.1016/s0006-8993(98)00202-9.

Abstract

N-chloroethyl derivatives of 7-hydroxy-1,2,3,4-tetrahydronaphthalene (7-OH-DPAT), 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), or fluphenazine were microinjected into rat nucleus accumbens (Acc), and receptor binding quantified autoradiographically after 24 h. EEDQ reduced [3H]nemonapride (D2-like receptors) binding in Acc (by 84%) and islands of Calleja (IC; 44%), without affecting [3H](+)-7-OH-DPAT (D3); N-chloroethyl-7-OH-DPATs blocked both radioligands in Acc and IC (30%-70%); fluphenazine had no effect.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkylating Agents / pharmacology*
  • Animals
  • Autoradiography
  • Bacterial Toxins / pharmacology
  • Calcium-Binding Proteins*
  • Dopamine Agonists / pharmacology
  • Dopamine Antagonists / pharmacology*
  • Fluphenazine / pharmacology
  • Male
  • Microinjections
  • Nucleus Accumbens / chemistry
  • Nucleus Accumbens / drug effects
  • Prosencephalon / chemistry*
  • Prosencephalon / drug effects
  • Quinolines / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D2 / physiology*
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes / pharmacology
  • Type C Phospholipases / pharmacology

Substances

  • Alkylating Agents
  • Bacterial Toxins
  • Calcium-Binding Proteins
  • Dopamine Agonists
  • Dopamine Antagonists
  • Drd3 protein, rat
  • Quinolines
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes
  • EEDQ
  • Type C Phospholipases
  • alpha toxin, Clostridium perfringens
  • 7-hydroxy-2-N,N-dipropylaminotetralin
  • Fluphenazine