Abstract
In vitro, cytosolic human ketone reductases catalyse the stereospecific (i.e. >99%) formation of S(-) reduced haloperidol (RHP) from haloperidol (HP). Whether this situation is reflected in patients taking the drug is unknown. In this study in nine patients taking HP, only 73.2+/-18.2% of the RHP excreted in urine was the S(-) enantiomer. Thus, enzymes other than cytosolic ketone reductases must be responsible for the formation of the minor enantiomer.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antipsychotic Agents / chemistry*
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Antipsychotic Agents / pharmacokinetics
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Antipsychotic Agents / urine
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Chromatography, High Pressure Liquid
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Haloperidol / analogs & derivatives*
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Haloperidol / chemistry
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Haloperidol / pharmacokinetics
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Haloperidol / urine
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Humans
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Male
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Middle Aged
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Oxidation-Reduction
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Stereoisomerism
Substances
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Antipsychotic Agents
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4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol
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Haloperidol