Translocation (3;5)(p26;q13) in a patient with chronic T-cell lymphoproliferative disorder

H H Schmidt; H Pirc-Danoewinata; E R Panzer-Grümayer; H Sill; P Sedlmayr; P Neumeister; W Linkesch; O A Haas

doi:10.1016/s0165-4608(97)00453-6

Translocation (3;5)(p26;q13) in a patient with chronic T-cell lymphoproliferative disorder

Cancer Genet Cytogenet. 1998 Jul 15;104(2):82-5. doi: 10.1016/s0165-4608(97)00453-6.

Authors

H H Schmidt¹, H Pirc-Danoewinata, E R Panzer-Grümayer, H Sill, P Sedlmayr, P Neumeister, W Linkesch, O A Haas

Affiliation

¹ Department of Internal Medicine, University of Graz, Austria.

PMID: 9666798
DOI: 10.1016/s0165-4608(97)00453-6

Abstract

A 67-year-old patient with large granular lymphocyte (LGL) leukemia is described. At fluorescence-activated cell sorting (FACS) analysis of the peripheral blood, the lymphocytes were positive for CD3, CD4, CD5, CD29, CD45RA, CD57, and TCR alpha/beta and negative for CD7, CD8, CD16, CD56, CD19, CD22, and TCR gamma/delta. Bone marrow histology and immunohistochemistry did not reveal any lymphocyte infiltration. Cytogenetic examination of peripheral blood cultures showed a clone with the karyotype 46,XY,t(3;5)(p26;q13). Molecular analysis revealed rearrangement of the gamma-T-cell-receptor chain. The region 3p25-3p26 which harbors the von Hippel-Lindau tumor suppressor gene and the RAF1 oncogene has been rearranged in a few cases of T-cell leukemia. The translocation in this case has not yet been described and may reflect an alternative mechanism in the pathogenesis of these disorders.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antigens, CD / immunology
Chromosomes, Human, Pair 3*
Chromosomes, Human, Pair 5*
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Lymphoid / genetics*
Leukemia, Lymphoid / immunology
Male
Translocation, Genetic*

Substances

Antigens, CD