Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes

Ann N Y Acad Sci. 1998 May 13:841:388-92. doi: 10.1111/j.1749-6632.1998.tb10951.x.

Authors

M Mihovilovic¹, S Denning, Y Mai, C M Fisher, L P Whichard, D D Patel, A D Roses

Affiliation

¹ Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

PMID: 9668263
DOI: 10.1111/j.1749-6632.1998.tb10951.x

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD4 Antigens / analysis
CD8 Antigens / analysis
Cells, Cultured
Epithelial Cells / physiology*
Humans
Macromolecular Substances
Neurons / physiology
Nicotine / pharmacology*
Receptors, Nicotinic / biosynthesis*
Receptors, Nicotinic / chemistry
Receptors, Nicotinic / genetics
T-Lymphocyte Subsets / physiology
T-Lymphocytes / drug effects
T-Lymphocytes / physiology*
Thymus Gland / cytology
Thymus Gland / physiology*
Transcription, Genetic*

Substances

CD4 Antigens
CD8 Antigens
Macromolecular Substances
Receptors, Nicotinic
Nicotine