Abstract
Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3' position of the inositol ring on phosphatidylinositol and higher-phosphorylated polyphosphoinositides. The multiplicity of cellular functions influenced by the activity of these enzymes has captured the attention of researchers working on two important fields of cell biology--signal transduction and membrane traffic. This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides has revealed novel potential interconnections between these fundamental cellular processes.
MeSH terms
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3-Phosphoinositide-Dependent Protein Kinases
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Adaptor Proteins, Signal Transducing
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Animals
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Biological Transport
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Carrier Proteins / metabolism
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Cell Membrane / metabolism
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Membrane Proteins / metabolism
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Nerve Tissue Proteins / metabolism
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Phosphatidylinositol 3-Kinases / metabolism*
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Phosphatidylinositol Phosphates / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Protein-Tyrosine Kinases / metabolism
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-akt
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Receptors, Cytoplasmic and Nuclear / metabolism
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Signal Transduction*
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Vesicular Transport Proteins
Substances
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ADAP1 protein, human
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Membrane Proteins
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Nerve Tissue Proteins
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Phosphatidylinositol Phosphates
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Proto-Oncogene Proteins
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Receptors, Cytoplasmic and Nuclear
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Vesicular Transport Proteins
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early endosome antigen 1
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phosphatidylinositol 3,4,5-triphosphate
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phosphatidylinositol receptors
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Tec protein-tyrosine kinase
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Protein-Tyrosine Kinases
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3-Phosphoinositide-Dependent Protein Kinases
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt