Abstract
A library of 2302 small molecule beta-turn mimetics was screened for inhibition of the alpha 4 beta 1 integrin-CS1 splice variant binding interaction. Preliminary data revealed several active ligands, and validation with purified material culminated in the identification of some of the first small molecule ligands (1, IC50 = 5 microM, and 2, IC50 = 8 microM) to be reported for this class of integrins.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alternative Splicing
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry
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Amino Acids / pharmacology
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Binding Sites
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Carboxylic Acids / chemical synthesis*
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Carboxylic Acids / chemistry
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Carboxylic Acids / pharmacology
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Databases as Topic*
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Drug Design
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Integrin alpha4beta1
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Integrins / antagonists & inhibitors*
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Integrins / chemistry
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Integrins / genetics*
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Ligands
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Molecular Conformation
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Molecular Structure
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Receptors, Lymphocyte Homing / antagonists & inhibitors*
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Receptors, Lymphocyte Homing / chemistry
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Receptors, Lymphocyte Homing / genetics*
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Receptors, Very Late Antigen / antagonists & inhibitors
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Receptors, Very Late Antigen / chemistry
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Receptors, Very Late Antigen / genetics
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Reproducibility of Results
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Amino Acids
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Carboxylic Acids
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Integrin alpha4beta1
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Integrins
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Ligands
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Receptors, Lymphocyte Homing
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Receptors, Very Late Antigen