Abstract
Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / virology
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Animals
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Antibodies, Monoclonal / immunology
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Antibodies, Viral / blood
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CD8-Positive T-Lymphocytes / immunology*
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Disease Progression
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Gene Products, gag / blood
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Humans
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Lymphocyte Count
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Lymphocyte Depletion
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Macaca mulatta
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Neutralization Tests
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RNA, Viral / blood
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Acquired Immunodeficiency Syndrome / virology*
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Simian Immunodeficiency Virus / immunology*
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Simian Immunodeficiency Virus / physiology
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T-Lymphocytes, Cytotoxic / immunology
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Time Factors
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Viral Load
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Viremia / immunology
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Viremia / virology
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Virus Replication
Substances
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Antibodies, Monoclonal
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Antibodies, Viral
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Gag protein p27, Simian immunodeficiency virus
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Gene Products, gag
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RNA, Viral