Chiu SH - Search Results

1

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA. Tang W, et al. Among authors: chiu sh. Drug Metab Dispos. 1999 Mar;27(3):365-72. Drug Metab Dispos. 1999. PMID: 10064567

2

Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.

Tang W, Stearns RA, Miller RR, Ngui JS, Mathvink RJ, Weber AE, Kwei GY, Strauss JR, Keohane CA, Doss GA, Chiu SH, Baillie TA. Tang W, et al. Among authors: chiu sh. Drug Metab Dispos. 2002 Jul;30(7):778-87. doi: 10.1124/dmd.30.7.778. Drug Metab Dispos. 2002. PMID: 12065436

3

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

Hop CE, Wang Y, Kumar S, Elipe MV, Raab CE, Dean DC, Poon GK, Keohane CA, Strauss J, Chiu SH, Curtis N, Elliott J, Gerhard U, Locker K, Morrison D, Mortishire-Smith R, Thomas S, Watt AP, Evans DC. Hop CE, et al. Among authors: chiu sh. Drug Metab Dispos. 2002 Aug;30(8):937-43. doi: 10.1124/dmd.30.8.937. Drug Metab Dispos. 2002. PMID: 12124313

4

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH. Huskey SE, et al. Among authors: chiu sh. Drug Metab Dispos. 2004 Feb;32(2):246-58. doi: 10.1124/dmd.32.2.246. Drug Metab Dispos. 2004. PMID: 14744948

5

The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices.

Stearns RA, Miller RR, Doss GA, Chakravarty PK, Rosegay A, Gatto GJ, Chiu SH. Stearns RA, et al. Among authors: chiu sh. Drug Metab Dispos. 1992 Mar-Apr;20(2):281-7. Drug Metab Dispos. 1992. PMID: 1352222

6

Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753.

Stearns RA, Doss GA, Miller RR, Chiu SH. Stearns RA, et al. Among authors: chiu sh. Drug Metab Dispos. 1991 Nov-Dec;19(6):1160-2. Drug Metab Dispos. 1991. PMID: 1687025 No abstract available.

7

Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members.

Stearns RA, Chakravarty PK, Chen R, Chiu SH. Stearns RA, et al. Among authors: chiu sh. Drug Metab Dispos. 1995 Feb;23(2):207-15. Drug Metab Dispos. 1995. PMID: 7736913

8

Mechanism of bioactivation and covalent binding of 2,4,6-trinitrotoluene.

Leung KH, Yao M, Stearns R, Chiu SH. Leung KH, et al. Among authors: chiu sh. Chem Biol Interact. 1995 Jun 30;97(1):37-51. doi: 10.1016/0009-2797(94)03606-9. Chem Biol Interact. 1995. PMID: 7767940

9

N-glucuronidation reactions. II. Relative N-glucuronidation reactivity of methylbiphenyl tetrazole, methylbiphenyl triazole, and methylbiphenyl imidazole in rat, monkey, and human hepatic microsomes.

Huskey SW, Doss GA, Miller RR, Schoen WR, Chiu SH. Huskey SW, et al. Among authors: chiu sh. Drug Metab Dispos. 1994 Jul-Aug;22(4):651-8. Drug Metab Dispos. 1994. PMID: 7956743

10

Evidence for a 1,2-hydride shift in the microsomal metabolism of the heterocycle L-158,338, a nonpeptide angiotensin II receptor antagonist.

Stearns RA, Miller RR, Arison BH, Rosegay A, Smith JL, Mantlo NB, Chiu SH. Stearns RA, et al. Among authors: chiu sh. Drug Metab Dispos. 1993 Jul-Aug;21(4):670-6. Drug Metab Dispos. 1993. PMID: 8104127

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