Huskey SE - Search Results

1

Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.

Pasternak A, Pan Y, Marino D, Sanderson PE, Mosley R, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Pasternak A, et al. Among authors: huskey se. Bioorg Med Chem Lett. 1999 Feb 8;9(3):491-6. doi: 10.1016/s0960-894x(99)00016-5. Bioorg Med Chem Lett. 1999. PMID: 10091708

2

Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.

Zhou C, Guo L, Morriello G, Pasternak A, Pan Y, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Zhou C, et al. Among authors: huskey se. Bioorg Med Chem Lett. 2001 Feb 12;11(3):415-7. doi: 10.1016/s0960-894x(00)00687-9. Bioorg Med Chem Lett. 2001. PMID: 11212124

3

Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor.

Liu K, Xu L, Szalkowski D, Li Z, Ding V, Kwei G, Huskey S, Moller DE, Heck JV, Zhang BB, Jones AB. Liu K, et al. J Med Chem. 2000 Sep 21;43(19):3487-94. doi: 10.1021/jm000285q. J Med Chem. 2000. PMID: 11000003

4

Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators.

Qureshi SA, Ding V, Li Z, Szalkowski D, Biazzo-Ashnault DE, Xie D, Saperstein R, Brady E, Huskey S, Shen X, Liu K, Xu L, Salituro GM, Heck JV, Moller DE, Jones AB, Zhang BB. Qureshi SA, et al. J Biol Chem. 2000 Nov 24;275(47):36590-5. doi: 10.1074/jbc.M006287200. J Biol Chem. 2000. PMID: 10967116 Free article.

5

The unanticipated loss of SO2 from sulfonamides in collision-induced dissociation.

Wang Z, Hop CE, Kim MS, Huskey SE, Baillie TA, Guan Z. Wang Z, et al. Among authors: huskey se. Rapid Commun Mass Spectrom. 2003;17(1):81-6. doi: 10.1002/rcm.877. Rapid Commun Mass Spectrom. 2003. PMID: 12478558

6

Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3.

Chu XY, Huskey SE, Braun MP, Sarkadi B, Evans DC, Evers R. Chu XY, et al. Among authors: huskey se. J Pharmacol Exp Ther. 2004 Apr;309(1):156-64. doi: 10.1124/jpet.103.062091. Epub 2004 Jan 13. J Pharmacol Exp Ther. 2004. PMID: 14722317

7

Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent.

Huskey SE, Forseth RR, Li H, Jian Z, Catoire A, Zhang J, Ray T, He H, Flarakos J, Mangold JB. Huskey SE, et al. Drug Metab Dispos. 2016 Oct;44(10):1697-708. doi: 10.1124/dmd.116.072108. Epub 2016 Aug 2. Drug Metab Dispos. 2016. PMID: 27486238

8

Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.

Flarakos J, Du Y, Bedman T, Al-Share Q, Jordaan P, Chandra P, Albrecht D, Wang L, Gu H, Einolf HJ, Huskey SE, Mangold JB. Flarakos J, et al. Among authors: huskey se. Xenobiotica. 2016 Nov;46(11):986-1000. doi: 10.3109/00498254.2015.1014944. Epub 2016 Mar 2. Xenobiotica. 2016. PMID: 26931777

9

KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.

Huskey SE, Zhu CQ, Fredenhagen A, Kühnöl J, Luneau A, Jian Z, Yang Z, Miao Z, Yang F, Jain JP, Sunkara G, Mangold JB, Stein DS. Huskey SE, et al. Drug Metab Dispos. 2016 May;44(5):672-82. doi: 10.1124/dmd.115.069187. Epub 2016 Feb 26. Drug Metab Dispos. 2016. PMID: 26921387

10

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.

Huskey SE, Zhu CQ, Lin MM, Forseth RR, Gu H, Simon O, Eggimann FK, Kittelmann M, Luneau A, Vargas A, Li H, Wang L, Einolf HJ, Zhang J, Favara S, He H, Mangold JB. Huskey SE, et al. Drug Metab Dispos. 2016 May;44(5):653-64. doi: 10.1124/dmd.115.069112. Epub 2016 Feb 26. Drug Metab Dispos. 2016. PMID: 26921386

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