Schaeffer JM - Search Results

1

Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.

Pasternak A, Pan Y, Marino D, Sanderson PE, Mosley R, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Pasternak A, et al. Among authors: schaeffer jm. Bioorg Med Chem Lett. 1999 Feb 8;9(3):491-6. doi: 10.1016/s0960-894x(99)00016-5. Bioorg Med Chem Lett. 1999. PMID: 10091708

2

Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.

Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML. Kim S, et al. Among authors: schaeffer jm. J Med Chem. 2004 Apr 22;47(9):2171-5. doi: 10.1021/jm034243o. J Med Chem. 2004. PMID: 15084115

3

Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.

Kim S, Wu J, Chen HY, Birzin ET, Chan W, Yang YT, Colwell L, Li S, Dahllund J, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML. Kim S, et al. Among authors: schaeffer jm. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2741-5. doi: 10.1016/j.bmcl.2004.03.074. Bioorg Med Chem Lett. 2004. PMID: 15125925

4

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.

Dykstra KD, Guo L, Birzin ET, Chan W, Yang YT, Hayes EC, DaSilva CA, Pai LY, Mosley RT, Kraker B, Fitzgerald PM, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML. Dykstra KD, et al. Among authors: schaeffer jm. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2322-8. doi: 10.1016/j.bmcl.2007.01.054. Epub 2007 Jan 25. Bioorg Med Chem Lett. 2007. PMID: 17289385

5

Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.

Yang L, Guo L, Pasternak A, Mosley R, Rohrer S, Birzin E, Foor F, Cheng K, Schaeffer J, Patchett AA. Yang L, et al. J Med Chem. 1998 Jun 18;41(13):2175-9. doi: 10.1021/jm980194h. J Med Chem. 1998. PMID: 9632348 No abstract available.

6

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.

Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA. Yang L, et al. Among authors: schaeffer jm. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41. doi: 10.1073/pnas.95.18.10836. Proc Natl Acad Sci U S A. 1998. PMID: 9724791 Free PMC article.

7

Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.

Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP. Ye Z, et al. Among authors: schaeffer jm. Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8. doi: 10.1016/s0960-894x(99)00584-3. Bioorg Med Chem Lett. 2000. PMID: 10636230

8

A combinatorial approach toward the discovery of non-peptide, subtype-selective somatostatin receptor ligands.

Berk SC, Rohrer SP, Degrado SJ, Birzin ET, Mosley RT, Hutchins SM, Pasternak A, Schaeffer JM, Underwood DJ, Chapman KT. Berk SC, et al. Among authors: schaeffer jm. J Comb Chem. 1999 Sep-Oct;1(5):388-96. doi: 10.1021/cc990017h. J Comb Chem. 1999. PMID: 10748735

9

Identification and characterization of subtype selective somatostatin receptor agonists.

Rohrer SP, Schaeffer JM. Rohrer SP, et al. Among authors: schaeffer jm. J Physiol Paris. 2000 May-Aug;94(3-4):211-5. doi: 10.1016/s0928-4257(00)00215-1. J Physiol Paris. 2000. PMID: 11087999

10

Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.

Zhou C, Guo L, Morriello G, Pasternak A, Pan Y, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Zhou C, et al. Among authors: schaeffer jm. Bioorg Med Chem Lett. 2001 Feb 12;11(3):415-7. doi: 10.1016/s0960-894x(00)00687-9. Bioorg Med Chem Lett. 2001. PMID: 11212124

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