Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication.
Garciarena CD, Malik A, Swietach P, Moreno AP, Vaughan-Jones RD.
Garciarena CD, et al. Among authors: malik a.
FASEB J. 2018 Apr;32(4):1969-1981. doi: 10.1096/fj.201700876R. Epub 2018 Jan 5.
FASEB J. 2018.
PMID: 29183963
Free PMC article.
To interrogate the effects of acidic and alkaline pH(i) on Cx43 channels, we combined voltage-clamp electrophysiology with pH(i) imaging and photolytic H(+) uncaging, performed over a range of pH(i) values. We demonstrate that Cx43 channels expressed in HeLa or N2a cell pa …
To interrogate the effects of acidic and alkaline pH(i) on Cx43 channels, we combined voltage-clamp electrophysiology with pH(i) imaging and …