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Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals.
Barja G, Herrero A. Barja G, et al. Among authors: herrero a. FASEB J. 2000 Feb;14(2):312-8. doi: 10.1096/fasebj.14.2.312. FASEB J. 2000. PMID: 10657987
However, 8-oxodG/dG in mtDNA was inversely correlated with MLSP both in heart (r=-0.92; P<0.001) and brain (r=-0.88; P<0.016) tissues following the power function y = a(.)x(b), where y is 8-oxodG/dG and x is the MLSP. This agrees with the consistent observation that …
However, 8-oxodG/dG in mtDNA was inversely correlated with MLSP both in heart (r=-0.92; P<0.001) and brain (r=-0.88; P<0.016) tissues …
669 results