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Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.
Lai WS, Carballo E, Strum JR, Kennington EA, Phillips RS, Blackshear PJ. Lai WS, et al. Among authors: carballo e. Mol Cell Biol. 1999 Jun;19(6):4311-23. doi: 10.1128/MCB.19.6.4311. Mol Cell Biol. 1999. PMID: 10330172 Free PMC article.
Macrophages derived from these mice oversecrete TNF-alpha, by a mechanism that involves stabilization of TNF-alpha mRNA, and TTP can bind directly to the AU-rich element (ARE) in TNF-alpha mRNA (E. Carballo, W. S. Lai, and P. J. Blackshear, Science 281:1001-1005, 19 …
Macrophages derived from these mice oversecrete TNF-alpha, by a mechanism that involves stabilization of TNF-alpha mRNA, and TTP can bind di …
Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction.
Carballo E, Gilkeson GS, Blackshear PJ. Carballo E, et al. J Clin Invest. 1997 Sep 1;100(5):986-95. doi: 10.1172/JCI119649. J Clin Invest. 1997. PMID: 9276715 Free PMC article.
Virtually the entire syndrome can be prevented by the repeated injection of anti-TNFalpha antibodies (Taylor, G.A., E. Carballo, D.M. Lee, W.S. Lai, M.J. Thompson, D.D. Patel, D.I. Schenkman, G.S. Gilkeson, H.E. Broxmeyer, B.F. Haynes, and P.J. Blackshear. 19 …
Virtually the entire syndrome can be prevented by the repeated injection of anti-TNFalpha antibodies (Taylor, G.A., E. Carballo
61 results