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Helicobacter pylori physiology predicted from genomic comparison of two strains.
Doig P, de Jonge BL, Alm RA, Brown ED, Uria-Nickelsen M, Noonan B, Mills SD, Tummino P, Carmel G, Guild BC, Moir DT, Vovis GF, Trust TJ. Doig P, et al. Among authors: tummino p. Microbiol Mol Biol Rev. 1999 Sep;63(3):675-707. doi: 10.1128/MMBR.63.3.675-707.1999. Microbiol Mol Biol Rev. 1999. PMID: 10477312 Free PMC article. Review.
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.
Alm RA, Ling LS, Moir DT, King BL, Brown ED, Doig PC, Smith DR, Noonan B, Guild BC, deJonge BL, Carmel G, Tummino PJ, Caruso A, Uria-Nickelsen M, Mills DM, Ives C, Gibson R, Merberg D, Mills SD, Jiang Q, Taylor DE, Vovis GF, Trust TJ. Alm RA, et al. Among authors: tummino pj. Nature. 1999 Jan 14;397(6715):176-80. doi: 10.1038/16495. Nature. 1999. PMID: 9923682
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
Leit S, Greenwood J, Carriero S, Mondal S, Abel R, Ashwell M, Blanchette H, Boyles NA, Cartwright M, Collis A, Feng S, Ghanakota P, Harriman GC, Hosagrahara V, Kaila N, Kapeller R, Rafi SB, Romero DL, Tarantino PM, Timaniya J, Toms AV, Wester RT, Westlin W, Srivastava B, Miao W, Tummino P, McElwee JJ, Edmondson SD, Masse CE. Leit S, et al. Among authors: tummino p. J Med Chem. 2023 Aug 10;66(15):10473-10496. doi: 10.1021/acs.jmedchem.3c00600. Epub 2023 Jul 10. J Med Chem. 2023. PMID: 37427891
Identification of Two Non-Peptidergic Small Molecule Inhibitors of CBX2 Binding to K27 Trimethylated Oligonucleosomes.
Lercher L, Simon N, Bergmann A, Tauchert M, Bochmann D, Bashir T, Neuefeind T, Riley D, Danna B, Krawczuk P, Pande V, Patrick A, Steele R, Wang W, Rupnow B, Tummino P, Sharma S, Finley M. Lercher L, et al. Among authors: tummino p. SLAS Discov. 2022 Jul;27(5):306-313. doi: 10.1016/j.slasd.2022.04.003. Epub 2022 May 2. SLAS Discov. 2022. PMID: 35513262 Free article.
MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers.
Wyce A, Matteo JJ, Foley SW, Felitsky DJ, Rajapurkar SR, Zhang XP, Musso MC, Korenchuk S, Karpinich NO, Keenan KM, Stern M, Mathew LK, McHugh CF, McCabe MT, Tummino PJ, Kruger RG, Carpenter C, Barbash O. Wyce A, et al. Among authors: tummino pj. Oncogenesis. 2018 Apr 20;7(4):35. doi: 10.1038/s41389-018-0043-9. Oncogenesis. 2018. PMID: 29674704 Free PMC article.
Small-Molecule Targets in Immuno-Oncology.
Dhanak D, Edwards JP, Nguyen A, Tummino PJ. Dhanak D, et al. Among authors: tummino pj. Cell Chem Biol. 2017 Sep 21;24(9):1148-1160. doi: 10.1016/j.chembiol.2017.08.019. Cell Chem Biol. 2017. PMID: 28938090 Free article. Review.
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
Mohammad HP, Smitheman KN, Kamat CD, Soong D, Federowicz KE, Van Aller GS, Schneck JL, Carson JD, Liu Y, Butticello M, Bonnette WG, Gorman SA, Degenhardt Y, Bai Y, McCabe MT, Pappalardi MB, Kasparec J, Tian X, McNulty KC, Rouse M, McDevitt P, Ho T, Crouthamel M, Hart TK, Concha NO, McHugh CF, Miller WH, Dhanak D, Tummino PJ, Carpenter CL, Johnson NW, Hann CL, Kruger RG. Mohammad HP, et al. Among authors: tummino pj. Cancer Cell. 2015 Jul 13;28(1):57-69. doi: 10.1016/j.ccell.2015.06.002. Cancer Cell. 2015. PMID: 26175415 Free article.
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.
Ott HM, Graves AP, Pappalardi MB, Huddleston M, Halsey WS, Hughes AM, Groy A, Dul E, Jiang Y, Bai Y, Annan R, Verma SK, Knight SD, Kruger RG, Dhanak D, Schwartz B, Tummino PJ, Creasy CL, McCabe MT. Ott HM, et al. Among authors: tummino pj. Mol Cancer Ther. 2014 Dec;13(12):3062-73. doi: 10.1158/1535-7163.MCT-13-0876. Epub 2014 Sep 24. Mol Cancer Ther. 2014. PMID: 25253781
72 results